KYA-1797K

SKU: orb1225782

Description

A derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling; dose-dependently decreases Wnt3a-CM-induced TOPflash reporter activation with IC50 of 0.75 uM; more effectively reduces the levels of both β-catenin and pan-Ras as well as the activities of ERK and Akt in SW480 cells; binds to Axin (Kd to WT axin-RGS=0.29 uM) and destabilizes b-catenin and Ras; inhibits growth of CRC cells with GI50 of 4-5 uM; suppresses the tumors induced by APC and KRAS mutations in tumor xenograft mice (25 mg/kg, i.p.).

Key Properties

• CAS Number: 1956356-56-1
• MW: 442.501
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₁KN₂O₆S₂
• SMILES: O=C([O-])CCN(C/1=O)C(SC1=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=S.[K+]
• Target: Beta-catenin
• Solubility: Ethanol: <1 mg/mL; DMSO: 20 mg/mL (45.2 mM); Water: 20 mg/mL (45.2 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KYA 1797K

Quick Database Links

Gene Symbol

Beta-catenin