KY19382

SKU: orb1298435

Description

KY19382 is a potent, orally bioavailable small molecule that dually inhibits the CXXC5-DVL interaction and GSK3β activity (IC50s of 19 and 10 nM), thereby activating Wnt/β-catenin signaling. It has been investigated in preclinical research for metabolic diseases, including studies using high-fat diet-induced in vivo models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2226664-93-1
• MW: 360.19
• Purity: 98.06% (May vary between batches)
• Formula: C₁₇H₁₁Cl₂N₃O₂
• SMILES: CO\N=C1/C(/Nc2ccccc/12)=C1/C(=O)Nc2cc(Cl)c(Cl)cc12
• Target: Wnt/beta-catenin,GSK-3
• Solubility: DMSO:5 mg/mL (13.88 mM)

Bioactivity

• Target IC50:
  CXXC5-DVL:10 nM|GSK-3β:10 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CXXC5-DVL, betacatenin, beta-catenin, bcatenin, A 3051, A3051, A-3051, 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382, GSK-3, GSK3, GSK-3β, KY 19382, KY19382, KY-19382, Wnt/β-catenin, Wnt/b-catenin, Wnt/betacatenin, Wnt, β-catenin, βcatenin

Compound Identifiers

PubChem CID

148959784