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KWZY-11

SKU: orb3135649

Description

KWZY-11 (Compound 11) is a potent dual inhibitor of PARP/CDK6, exhibiting IC50 values of 156.8 nM, 197.3 nM, and 13.3 nM for PARP1, PARP2, and CDK6 respectively. It suppresses tumor cell proliferation by modulating the Wnt/β-catenin signaling pathway. Additionally, KWZY-11 induces excessive DNA damage and apoptosis in MDA-MB-231 breast cancer cells.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

TargetCDK,PARP,Apoptosis,Wnt/beta-catenin

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Protocol Information