KWR137

SKU: orb2944425

Description

KWR137 is a potent WRN degrader (IC50 = 8 nM) with antiproliferative activity in MSI-H cells, such as SW48 (GI50 = 509 nM), and demonstrates antitumor efficacy in xenograft models, making it a valuable tool for cancer research, particularly in DNA damage response and synthetic lethality studies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• MW: 710.105
• Formula: C₃₃H₃₁ClF₃N₉O₄
• SMILES: O=C1C(N2CCN(C(C3=CC(N=CC=C4)=C4N3)=O)CC2)=C(CC)N(CC(NC5=CC=C(C(F)(F)F)C=C5Cl)=O)C6=NC(C7=CCOCC7)=NN61
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176455404