Kuwanon E

SKU: orb1684469

Description

Kuwanon E, a flavonoid isolated from Morus alba, exhibits anti-inflammatory properties by inhibiting TNF-α and IL-1β release and blocking NF-κB nuclear translocation in LPS-activated macrophages. This compound is a valuable research tool for studying inflammatory pathways in cellular models and has shown activity in preclinical models of inflammation.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 68401-05-8
• MW: 424.49
• Purity: 98.37% (May vary between batches)
• Formula: C₂₅H₂₈O₆
• SMILES: CC(C)=CCC\C(C)=C\Cc1cc(C2CC(=O)c3c(O)cc(O)cc3O2)c(O)cc1O
• Target: IL Receptor,TNF
• Solubility: DMSO:30 mg/mL (70.67 mM)

Bioactivity

• In Vitro:
  METHODS: THP-1 cells were exposed to different concentrations of Kuwanon E (1, 2.5, 5, 10, 20, and 50 μM) for 24 hours, stained for activity, and counted using a hemocytometer. RESULTS: The LD50 value of Kuwanon E was greater than 50 μM and inhibited the proliferation of THP-1 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AChE, BChE, IL Receptor, Kuwanon E, ILReceptor, IL-1β, TNF-α

Compound Identifiers

PubChem CID

10342292