Kurarinone

SKU: orb1301313

Description

Kurarinone

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 34981-26-5
• MW: 438.51
• Purity: 98.00%
• Formula: C₂₆H₃₀O₆
• SMILES: COc1cc(O)c(C[C@@H](CC=C(C)C)C(C)=C)c2O[C@@H](CC(=O)c12)c1ccc(O)cc1O
• Target: IκB/IKK,PERK,TNF,Bcl-2 Family,JAK,STAT,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.56 mM);DMSO:55 mg/mL (125.42 mM)

Bioactivity

• In Vivo:
  METHODS: Arthritis was reproduced in DBA/1 mice by inducing bovine type II collagen (CII) as a collagen-induced arthritis (CIA) model. After establishment of CIA, kurarinone (100 mg/kg/day) was administered orally from day 21 to day 42, and severity was determined based on symptom scoring scales and histopathology. ELISA and flow cytometry were used to detect the cytokine levels, anti-cii antibody levels, and T cell proliferation and lineage in the draining lymph nodes, respectively. RESULTS kurarinone treatment reduced the severity of arthritis in CIA mice and reduced the levels of pro-inflammatory cytokines TNF-α, IL-6, IFN-γ and IL-17A in serum and foot tissue.
• In Vitro:
  METHODS: To test the cytotoxicity of kurarinone on HMC3 cells, we treated HMC3 cells with different concentrations of kurarinone (10, 20, 40 or 80 μM) for 24 hours. RESULTS HMC3 cell viability was reduced after treatment with 80 μM Kur. METHODS: Two human small cell lung cancer (SCLC) cell lines H1688 and H146, and an immortalized bronchial epithelial cell line BEAS-2B were treated with different concentrations of kurarinone (3.125 ~ 50 μM), and the IC50 was determined. RESULTS The IC50 values of kurarinone against H1688, H146 and BEAS-2B cells were 12.5±4.7, 30.4±5.1 and 55.8±4.9 μM respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bcl-2, CD4(+), inhibit, Kurarinone, IκB, JAK, NFκB, NF-kB, NFkB, NF-κB, Inhibitor, IkB/IKK, IkB, IKK, TNF-α, STAT

Compound Identifiers

PubChem CID

11982640