Kumatakenin

SKU: orb1297309

Description

Kumatakenin demonstrates potent inhibitory activity against Trp-P-1-induced SOS response, achieving over 80% suppression at concentrations below 0.06 µM. This flavonoid is a valuable research tool for investigating genotoxicity, mutagenesis, and chemopreventive mechanisms in both cellular and biochemical assays.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 3301-49-3
• MW: 314.29
• Purity: 98.41% (May vary between batches)
• Formula: C₁₇H₁₄O₆
• SMILES: COc1cc(O)c2c(c1)oc(-c1ccc(O)cc1)c(OC)c2=O
• Target: Apoptosis,Anti-infection
• Solubility: DMSO:60 mg/mL (190.91 mM)

Bioactivity

• In Vitro:
  The methanol extract was re-extracted with hexane, dichloromethane, butanol, and water. A dichloromethane fraction showed a suppressive effect. Suppressive compounds against furylfuramide in the dichloromethane fraction were isolated by SiO(2) column chromatography and identified as 7,4'-di-O-methyleriodictyol (1), 7, 3',4'-tri-O-methyleriodictyol (2), and 3,7,4'-tri-O-methylkaempferol (3). In addition, three flavonoids, ombuine (4), pachypodol (5), and Kumatakenin (6), were isolated and identified from the dichrolomethane fraction. Compounds 1 and 3 suppressed >50% of the SOS-inducing activity at <0.6 micromol/mL, and the ID(50) values of both compounds were 0.25 micromol/mL. Compound 2 showed a weakly suppressive effect (17%) at a concentration of 0.6 micromol/mL, and compounds 4-6 did not. These compounds were also assayed with 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which requires liver metabolizing enzymes. Compounds 3,4,5,Kumatakenin (6) suppressed >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL, and compounds 1 and 2 suppressed 87 and 63% at a concentration of 0.3 micromol/mL. In addition, these compounds were assayed with activated Trp-P-1, and the suppressed effects of these compounds were further decreased when compared to Trp-P-1.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cell, cancer, Apoptosis, Anti-infection, Antiinfection, Inhibitor, Kaempferol 3,7-O-dimethyl ether, inhibit, Kumatakenin, Jaranol, ovarian

Compound Identifiers

PubChem CID

5318869