KU004

SKU: orb2663555

Description

KU004 is a novel quinazoline-based dual EGFR/HER2 inhibitor. It demonstrates anticancer activity by blocking HER2/EGFR and downstream Akt/Erk signaling, inducing G1 arrest and extrinsic apoptosis in SKBR3 breast cancer cells in vitro. This mechanism supports its research use in studying targeted oncology pathways.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1260401-93-1
• MW: 548.98
• Formula: C₂₉H₂₇ClFN₄O₂P
• SMILES: O=P1(C)CCN(CC#CC=2C=CC3=NC=NC(NC4=CC=C(OCC=5C=CC=C(F)C5)C(Cl)=C4)=C3C2)CC1
• Target: Apoptosis,Akt,ERK,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

49837706