KU-0063794

SKU: orb1223584

Description

A potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2; displays no activity against 76 other protein kinases or seven lipid kinases, including class 1 PI3Ks (>1,000-fold); suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK, also inhibits phosphorylation of the T-loop Thr308 of Akt, induces complete dephosphorylation of 4E-BP1 in HEK-293 cells; suppresses cell growth and induces G1-cell cycle arrest in both wild-type and mLST8 deficient MEFs.

Key Properties

• CAS Number: 938440-64-3
• MW: 465.5447
• Purity: >98% (HPLC)
• Formula: C₂₅H₃₁N₅O₄
• SMILES: OCC1=CC(C2=NC3=NC(N4C[C@@H](C)O[C@@H](C)C4)=NC(N5CCOCC5)=C3C=C2)=CC=C1OC
• Target: mTOR
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KU 0063794 | KU0063794

Quick Database Links

Gene Symbol

mTOR