KT-5720

SKU: orb2656004

Description

KT-5720 is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM); reversibly arrests human skin fibroblasts in the G1 phase.

Key Properties

• CAS Number: 108068-98-0
• MW: 537.605
• Purity: >98% (HPLC)
• Formula: C₃₂H₃₁N₃O₅
• SMILES: O=C([C@](C[C@@](O1)([H])N2C3=CC=CC=C43)(O)[C@]1(C)N5C6=CC=CC=C6C7=C5C2=C4C8=C7CNC8=O)OCCCCCC
• Target: PKA
• Solubility: In Vitro: Methanol :5 mg/mL (9.30 mM)

Bioactivity

• In Vivo:
  Animal model: MDR1 transgenic mice model. Dosage: 5 mg/kg. Administration: Intraperitoneal injection; single daily for 8 days. Result: Exhibited the leukopenia induced by daunorubicin in the MDR mice was equivalent to that measured in non-MDR mice treated with daunorubicin alone.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KT5720

Quick Database Links

Gene Symbol

PKA