KT-253

SKU: orb2945769

Description

KT-253 is a bifunctional small molecule that stabilizes p53 and potently degrades MDM2 via cereblon recruitment (DC50=0.4 nM). It demonstrates potent anti-proliferative activity (IC50=0.3 nM in RS4;11 cells), inducing G2/M arrest and apoptosis, with confirmed antitumor efficacy in mouse models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2713618-08-5
• MW: 912.874
• Formula: C₄₈H₅₂Cl₂FN₇O₆
• SMILES: O=C1[C@@]2(C3(N[C@@H](C(N[C@@H]4CC[C@@H](C(=O)N5CCC(CC5)C=6C=C7C(=CC6)N(C(=O)N7C)C8C(=O)NC(=O)CC8)CC4)=O)[C@@H]2C9=C(F)C(Cl)=CC=C9)CCCCC3)C=%10C(N1)=CC(Cl)=CC%10
• Target: MDM-2/p53,Apoptosis,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166753033