KSI-3716

SKU: orb1709313

Description

KSI-3716

Research Area

Cell Biology

Key Properties

• CAS Number: 1151813-61-4
• MW: 426.09
• Purity: 98.94% (May vary between batches)
• Formula: C₁₇H₁₁BrCl₂N₂O₂
• SMILES: O=C1C=2C(Cl)=CC=C(Br)C2NC(NC3=CC=C(Cl)C=C3)=C1C(=O)C
• Target: c-Myc,Autophagy
• Solubility: DMSO:2 mg/mL (4.69 mM)

Bioactivity

• Target IC50:
  c-Myc:0.86 μM
• In Vivo:
  KSI-3716 was injected into the bladder of mice xenografted with bladder cancer at a dose of 5 mg/kg, and it was observed that it could significantly inhibit tumor growth and had little systemic toxicity.
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• In Vitro:
  KSI-3716 is a potent c-Myc inhibitor that blocks the binding of c-MYC/MAX to target gene promoters. KSI-3716 is used as an intravesical chemotherapy agent. KSI-3716 effectively blocks complex formation in a dose-dependent manner, IC50 0.86 μM. C-myc-mediated transcription activity was inhibited by KSI-3716 at concentrations as low as 1 μM. KSI-3716 has cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KSI 3716, KSI3716, KSI-3716, cMyc, c-Myc

Compound Identifiers

PubChem CID

44565901