KRM-III

SKU: orb1694232

Description

KRM-III is an orally bioavailable small molecule that suppresses T cell activation and proliferation by inhibiting TCR and PMA/ionomycin-induced NFAT signaling, with an IC50 of ~5 µM. It serves as a valuable research tool for studying T cell-mediated immune responses in both in vitro assays and in vivo inflammatory disease models.

Key Properties

• CAS Number: 79220-94-3
• MW: 252.33
• Purity: 99.97% (May vary between batches)
• Formula: C₁₅H₁₂N₂S
• SMILES: S=c1[nH]c(cn1-c1ccccc1)-c1ccccc1
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.93 mM);DMSO:25.23 mg/mL (99.99 mM)

Bioactivity

• Target IC50:
  Proliferation (T-cells):~5 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KRM III, KRMIII, KRM-III, Nuclear factor of activated Tcells (NFAT)

Compound Identifiers

PubChem CID

736689