KRC-108

SKU: orb1738098

Description

KRC-108 is a multi-kinase inhibitor targeting Ron, Flt3, TrkA, and c-Met, with enhanced activity against oncogenic c-Met mutants. It demonstrates potent anti-proliferative effects in vitro (GI₅₀ 0.01-4.22 µM) and inhibits tumor growth in HT29 and NCI-H441 xenograft models, supporting its role as a lead compound in oncology research.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1146944-35-5
• MW: 360.41
• Formula: C₂₀H₂₀N₆O
• SMILES: NC1=C(C2=NC=3C(O2)=CC=CC3)C=C(C=N1)C4=CN(N=C4)C5CCNCC5
• Target: c-Met/HGFR,Others,FLT,Apoptosis,Autophagy,Trk receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

44160137