KRC-00715

SKU: orb2665251

Description

KRC-00715 is a potent and selective oral c-Met inhibitor (IC50 = 9.0 nM). It suppresses proliferation in c-Met-high gastric cancer cells like Hs746T (IC50 = 39 nM) via G1/S arrest and inhibits Akt/Erk signaling. The compound also demonstrates in vivo efficacy by reducing tumor growth in Hs746T xenograft models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2079853-72-6
• MW: 542.51
• Formula: C₂₅H₂₅F₃N₈O₃
• SMILES: FC(F)(F)C=1C=C(C=CC1OCCN2CCOCC2)C3=NC4=C(N=NN4CC5OC6=CC=CN=C6NC5)N=C3
• Target: c-Met/HGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172638549