KRASG12C IN-19

SKU: orb3174444

Description

KRASG12C IN-19 is a selective inhibitor of KRASG12C. It exhibits potent antiproliferative activity against the KRASG12C-mutant non-small cell lung cancer (NSCLC) cell line H358, with an IC50 of 7.6 nM, and effectively inhibits downstream ERK phosphorylation (IC50= 24.06 nM). It shows no significant inhibitory activity on KRASG12V and KRASG12D mutant cancer cells (PANC 1, Panc 03.27, AsPC 1, and GP2d cells) with IC50 values greater than 10,000 nM. KRASG12C IN-19 rapidly forms a covalent bond with KRASG12V-GDP, leading to dose-dependent inhibition of the downstream KRAS pathway. This compound is suitable for research on KRASG12C-driven cancers, including non-small cell lung cancer, pancreatic cancer, and colorectal cancer.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2915282-32-3
• MW: 590.66
• Formula: C₃₃H₃₁FN₈O₂
• SMILES: O=C1N(C=2C(=NC=NC2C3CC3)C4CC4)C=5C(C(=N1)N6[C@@H](C)CN(C(C=C)=O)[C@H](C)C6)=CC(C#N)=C(N5)C7=C(F)C=CC=C7
• Target: ROS,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,ERK