KRASG12C IN-17

SKU: orb3173929

Description

KRASG12C IN-17 is an orally active covalent inhibitor of KRASG12C, demonstrating potent inhibitory activity in KRASG12C-mutant cancer cells (NCI-H23 IC50 = 0.7 nM; NCI-H358 IC50 = 0.5 nM). It efficiently and irreversibly forms a covalent bond with KRASG12C in both GDP-bound and GMPPNP-bound states, with a modification rate exceeding 96%. KRASG12C IN-17 is applicable for research on KRAS-driven tumors, including colorectal cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2966924-23-0
• MW: 650.71
• Formula: C₃₇H₃₃F₃N₆O₂
• SMILES: C(OC=1N=C(C2=C(N1)C(F)=C(C(F)=C2)C=3C4=C(C=CC3)C=CC=C4C#C)N5C[C@H](CC#N)N(C(C(=C)F)=O)CC5)C67N(CCC6)CCC7
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras