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KRASG12C IN-14

SKU: orb2665417

Description

KRASG12C IN-14 (compound 15) is a potent and selective inhibitor of the KRAS G12C mutant. It effectively disrupts the CYPA-dependent KRAS-BRAF interaction and suppresses ERK phosphorylation in NCI-H358 cells with an IC50 of 2 nM. This tool compound is valuable for in vitro mechanistic studies and exploring targeted oncology pathways in KRAS-driven cancers.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

MW1088.24
FormulaC51H65F4N9O9S2
TargetRas

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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KRASG12C IN-14 (orb2665417)

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