KRASG12C IN-14

SKU: orb2665417

Description

KRASG12C IN-14 (compound 15) is a potent and selective inhibitor of the KRAS G12C mutant. It effectively disrupts the CYPA-dependent KRAS-BRAF interaction and suppresses ERK phosphorylation in NCI-H358 cells with an IC50 of 2 nM. This tool compound is valuable for in vitro mechanistic studies and exploring targeted oncology pathways in KRAS-driven cancers.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 1088.24
• Formula: C₅₁H₆₅F₄N₉O₉S₂
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras