Kras4B G12D-IN-1

SKU: orb1944633

Description

Kras4B G12D-IN-1 is a selective small molecule inhibitor targeting the oncogenic Kras4B G12D mutant protein. It has been shown to reduce Kras protein expression in mutant-harboring MEFs in vitro and serves as a valuable chemical probe for studying KRAS-driven cancers in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2042365-85-3
• MW: 372.87
• Purity: 99.75% (May vary between batches)
• Formula: C₁₆H₂₁ClN₂O₄S
• SMILES: C(=O)(C1=C(OC)C=CC(Cl)=C1)N2C[C@@H](CNS(C=C)(=O)=O)CCC2
• Target: Kras,Ras
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.85 mM);DMSO:80 mg/mL (214.55 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KRAS G12D

Compound Identifiers

PubChem CID

145184470