KRAS inhibitor-37

SKU: orb2695292

Description

KRAS inhibitor-37 is a potent small molecule with sub-nanomolar affinity for multiple KRAS mutants, including G12D, G12C, and G12V. It demonstrates strong anti-proliferative activity in various cancer cell lines (IC50 <2-14 nM), making it a valuable tool for in vitro and in vivo oncology research targeting RAS-driven cancers.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3058573-95-5
• MW: 618.10
• Formula: C₃₂H₃₃ClFN₇O₃
• SMILES: FC=1C=2C3=C(N4[C@](COC3=NC1C=5C(=C(Cl)C=C6C5C=NN6)C7CC7)(COCCC4)[H])N=C(OC[C@@]89N(CC(=C)C8)CCC9)N2
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172194214