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KRAS inhibitor-3

SKU: orb1744760

Description

KRAS inhibitor-3, an efficacious inhibitor of both wild-type (WT) and oncogenic KRAS mutations, exhibits high-affinity binding (K D: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, and 0.74 μM for KRAS Q61H). Additionally, it impedes the interaction between KRAS and Raf, highlighting its potential as a targeted therapeutic agent in KRAS-mutant cancers.

Images & Validation

Key Properties

CAS Number900897-56-5
MW413.51
FormulaC25H27N5O
SMILESCc1nn2c(cc(nc2c1-c1ccccc1)-c1ccccc1)N1CCN(CCO)CC1
TargetRas,Others,Kras

Storage & Handling

Storage-20°C
DisclaimerFor research use only

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KRAS inhibitor-3 (orb1744760)

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