KRAS inhibitor-27

SKU: orb2945013

Description

KRAS inhibitor-27 (Compound 15h) is a potent small molecule targeting KRAS G12D/G12V mutations and wild-type KRAS, inhibiting MAPK signaling via ERK phosphorylation and DUSP4 reduction. It is a valuable tool for in vitro cancer research, particularly in studying pancreatic and colorectal cancer cell models like AsPC-1, SW620, and HT-29.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3033690-83-1
• MW: 657.106
• Formula: C₃₁H₂₈ClF₃N₆O₃S
• SMILES: N#CC1=C(SC2=C(F)C=CC(C=3C(F)=C4N=C(N=C5C4=C(OCC6N5CCCOC6)C3Cl)OCC78N(CCC7)CC(F)C8)=C12)N
• Target: ERK,p38 MAPK,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176455455