KRAS-IN-55

SKU: orb3211148

Description

KRAS-IN-55 is a broad-spectrum KRAS inhibitor with IC50 values of 4.3 nM for KRASG12C, 9.6 nM for KRASG12D, and 1.6 nM for KRASG12V. It induces the formation of a new binding pocket on KRAS, allowing for the creation of a high-affinity ternary complex with cyclophilin A (CYPA), thereby inhibiting the interaction between KRAS and downstream effectors RAF and PI3K, as well as blocking oncogenic MAPK and PI3K signaling pathways. KRAS-IN-55 is applicable in research concerning cancers such as colorectal cancer and non-small cell lung cancer.

Key Properties

• Target: p38 MAPK,Raf,PI3K,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

p38 MAPK,Raf,PI3K,Ras