KRAS-IN-54

SKU: orb3210900

Description

KRAS-IN-54 is a macrocyclic inhibitor of KRAS that shows activity in cell viability and pERK inhibition assays specifically targeting KRASG12D and KRASG13D mutations. It is applicable in research on KRAS-mutant cancers, including pancreatic adenocarcinoma, colorectal cancer, non-small cell lung cancer, esophageal cancer, gallbladder cancer, melanoma, ovarian cancer, and endometrial cancer.

Key Properties

• CAS Number: 3084918-70-4
• MW: 1192.39
• Formula: C₆₀H₇₈F₅N₁₁O₇S
• SMILES: O=C1OCC(C)(C)CC=2C=3C=C(C(F)=CC3N(C2C4=CC(=CN=C4C(OC)C)N5CCN(C)CC5)CC(F)(F)F)C=6N=C(SC6)CC(NC(=O)C(N(C(=O)C7(F)CCN(C(=O)C8N(C)C8C9CC9)CC7)C)C%10CCCC%10)C(=O)N%11NC1CCC%11
• Target: Ras,PERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras,PERK