KRAS-IN-51

SKU: orb3175076

Description

KRAS-IN-51 (Compound 597a) is a KRas G12V inhibitor with an IC50 of 2.9 nM for KRas G12V. It has KD values of 17 nM at 20°C and 68 nM at 37°C. KRAS-IN-51 inhibits the phosphorylation of pERK and exhibits antiproliferative activity against SW620 and MIAPaCa-2 cell lines. This compound is applicable for research in colorectal cancer and pancreatic cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3076211-50-9
• MW: 562.69
• Formula: C₃₁H₃₉FN₆O₃
• SMILES: C(#N)C1=C2[C@@]3(CC=4C(CO3)=C(N=C(OC[C@@]56N(C[C@H](F)C5)CCC6)N4)N7[C@](CO)(C)CC7)CC[C@H](C)C2=CC=C1N
• Target: Ras,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras,ERK