KRAS-IN-48 free base

SKU: orb3174979

Description

KRAS-IN-48 free base (Compound 1-01) is a mutant KRAS inhibitor with a Kd value of 2.58 nM for KRAS G12D and 5.49 μM for KRAS G12V. It affects pERK expression in cells harboring KRAS G12D and KRAS G12V mutations, with IC50 values of 1.1 μM and 1.51 μM respectively. This compound is applicable in cancer research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3074833-86-3
• MW: 641.72
• Formula: C₃₅H₃₇F₂N₇O₃
• SMILES: O(C=1N(C2=C(N=C(OC[C@@]34N(C[C@H](F)C3)CCC4)N=C2N1)N5CC6NC(C5)CC6)C7CCC7)C=8C9=C(C=C(O)C8)C=CC(F)=C9C#C
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras