KRAS G13D-IN-1

SKU: orb3133435

Description

KRAS G13D-IN-1 (compound 41) is a selective and covalent reversible inhibitor of KRASG13D with an IC50 value of 0.41 nM, exhibiting 29-fold selectivity over wild-type KRAS. It acts as a GDP-state inhibitor and targets the SWII binding pocket of KRASG13D. KRAS G13D-IN-1 inhibits GDP binding to KRAS and modulates downstream signaling cascades.

Research Area

Signal Transduction

Key Properties

• Formula: C₄₃H₄₅ClF₄N₈O₂
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras