KRAS G12D inhibitor 25

SKU: orb2695545

Description

This small molecule inhibitor targets KRAS G12C and HSP90α with IC50 values below 0.1 μM and in the 0.1-1 μM range, respectively. It demonstrates potent anti-proliferative activity against MIA PaCa-2 and NCI-H358 cancer cell lines and induces ERBB2 degradation, making it a useful tool for oncology research in vitro.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2768099-61-0
• MW: 1020.62
• Formula: C₅₆H₆₂ClN₁₁O₆
• SMILES: O(C[C@H]1CN(C(=O)C2CCN(CC3=CC=C(C=C3)N4C(=NNC4=O)C5=CC(C(C)C)=C(O)C=C5O)CC2)CCC1)C6=NC(=C7C(CN(CC7)C=8C9=C(C=CC8)C=CC=C9Cl)=N6)N%10C[C@H](CC#N)N(C(C=C)=O)CC%10
• Target: EGFR,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

167010856