KRAS G12C-IN-78

SKU: orb3211072

Description

KRAS G12C-IN-77 is a selective dual-state covalent inhibitor for KRASG12C, capable of binding with high affinity to the GDP-bound (inactive state) [IC50= 7 nM] and GTP-bound (active state) [IC50= 4 nM] forms of KRASG12C. It swiftly inhibits ERK1/2 phosphorylation, induces covalent adduct formation with endogenous KRASG12C, suppresses MAPK pathway gene expression, and inhibits the proliferation of KRASG12C-mutant cells. KRAS G12C-IN-77 is applicable in research concerning KRASG12C-mutant solid tumors, including pancreatic ductal adenocarcinoma and non-small cell lung cancer.

Key Properties

• CAS Number: 3023465-20-2
• MW: 729.75
• Formula: C₃₇H₃₁F₄N₇O₃S
• SMILES: C(OC=1N=C(C2=C(N1)C(F)=C(N=C2)C=3C4=C(C=C(O)C3)C=CC(F)=C4C#C)N5CCN(C(/C(=C/C6=NC=CS6)/F)=O)CC5)[C@@]78N(C[C@H](F)C7)CCC8
• Target: p38 MAPK,Ras,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

p38 MAPK,Ras,ERK