KRAS G12C-IN-74

SKU: orb3211152

Description

KRAS G12C-IN-74 is an orally active, selective inhibitor of KRASG12C with a target IC50 of 43.18 nM. It induces G0/G1 cell cycle arrest and apoptosis (apoptosis) in cancer cells harboring the KRASG12C mutation. KRAS G12C-IN-74 is applicable for research in KRASG12C-mutant pancreatic cancer, colorectal cancer, and lung cancer.

Key Properties

• CAS Number: 3085516-79-3
• MW: 615.76
• Formula: C₃₃H₃₈FN₇O₂S
• SMILES: C(OC1=NC(=C2C(=N1)CN(CC2)C3=C4C(SC=C4C)=CC=C3)N5C[C@H](CC#N)N(C(C(=C)F)=O)CC5)C67N(CCC6)CCC7
• Target: Apoptosis,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Ras