KR-33493

SKU: orb1296121

Description

KR-33493

Research Area

Cell Biology

Key Properties

• CAS Number: 1021497-97-1
• MW: 460.34
• Purity: 99.96%
• Formula: C₂₀H₁₈BrN₃O₃S
• SMILES: OC(=O)c1nn(CCc2ccccc2)cc1NC(=O)CSc1ccc(Br)cc1
• Target: Fas/FasL,TNF
• Solubility: DMSO:28 mg/mL (60.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.34 mM)

Bioactivity

• In Vivo:
  In Sprague Dawley (SD) rats, KR-33493(500 and 1000 mg/kg; oral) shows no significant Changes including Bodyweight changes, hematology, serum biochemistry, and urinalysis. In dogs, red blood cell count value in Males is significantly higher a the 1000 mg/kg/day dose with KR-33493 and is recovered afte the end o the administration perio.
• In Vitro:
  Bodyweight Changes of both sexes are not related to KR-33493 in All doses. In rats administrated KR-33493 for 4 weeks, no test article-related Changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in Males is significantly higher a the 1000 mg/kg/day dose than that o the control group (i.e., 6.9 ± .323 vs. 6.1 ± .418). however the change of RBC is recovered afte the end o the administration period.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

KM 819, KM819, KM-819, KR 33493, KR 33494, KR33493, KR-33493, KR33494, KR-33494, FAF1, Fas, FasL, Fas/FasL

Compound Identifiers

PubChem CID

25009726