KR-33493

SKU: orb1296121

Description

KR-33493 is a small molecule inhibitor of FAS-associated factor 1 (FAF1). It serves as a research tool for investigating Parkinson's disease, with applications in both in vitro biochemical assays and in vivo model studies to explore neuroprotective pathways.

Research Area

Cell Biology

Key Properties

• CAS Number: 1021497-97-1
• MW: 460.34
• Purity: 99.96% (May vary between batches)
• Formula: C₂₀H₁₈BrN₃O₃S
• SMILES: OC(=O)c1nn(CCc2ccccc2)cc1NC(=O)CSc1ccc(Br)cc1
• Target: TNF,Fas/FasL
• Solubility: DMSO:28 mg/mL (60.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.34 mM)

Bioactivity

• In Vivo:
  In Sprague-Dawley (SD) rats, KR-33493(500 and 1000 mg/kg; oral) shows no significant changes including Bodyweight changes, hematology, serum biochemistry, and urinalysis. In dogs, red blood cell count value in males is significantly higher at the 1000 mg/kg/day dose with KR-33493 and is recovered after the end of the administration period.
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• In Vitro:
  Bodyweight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KM 819, KM819, KM-819, KR 33493, KR 33494, KR33493, KR-33493, KR33494, KR-33494, FAF1, Fas, FasL, Fas/FasL

Compound Identifiers

PubChem CID

25009726