KPT-6566

SKU: orb1301363

Description

KPT-6566

Key Properties

• CAS Number: 881487-77-0
• MW: 443.54
• Purity: 97.81% (May vary between batches)
• Formula: C₂₂H₂₁NO₅S₂
• SMILES: CC(C)(C)c1ccc(cc1)S(=O)(=O)\N=C1/C=C(SCC(O)=O)C(=O)c2ccccc12
• Target: Others
• Solubility: 10% DMSO+90% Saline:1 mg/mL (2.25 mM);DMSO:120 mg/mL (270.55 mM)

Bioactivity

• Target IC50:
  PIN1 PPIase:640 nM
• In Vitro:
  KPT-6566 covalently binds to the catalytic site of PIN1,inhibited the PPIase activity of PIN1 and turned out to have an IC50 of 0.64 μM. This interaction results in the release of a quinone-mimicking drug that generates reactive oxygen species and DNA damage, inducing cell death specifically in cancer cells.
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• Cell Research:
  For IC50 determination, human recombinant PIN1 was preincubated with different concentrations of KPT-6566 and PPIase activity was measured after 180 min. K values of PPIase activity were plotted against inhibitor concentration in a semi-logarithmic plot.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROS, pin1, anti- proliferation, breast epithelial, DNA damage, Cyclin D1, inhibit, KPT 6566, KPT6566, KPT-6566, Inhibitor

Compound Identifiers

PubChem CID

1652783