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KOR agonist 6

SKU: orb3136904

Description

KOR agonist 6 is a KOR agonist with a Ki value of 0.25 pM. In CHO cells, it exhibits agonistic activity on MOR and DOR and inhibits forskolin-stimulated cAMP accumulation. The compound stimulates KOR-mediated [35S]GTPγS binding in HEK293 cells expressing KOR and effectively suppresses cAMP accumulation as a potent agonist, showing lower β-arrestin recruitment efficacy. Additionally, KOR agonist 6 demonstrates analgesic effects in mice and can be employed in the study of analgesics with reduced central nervous system (CNS) side effects.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

TargetOpioid Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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KOR agonist 6 (orb3136904)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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