KO-947

SKU: orb1296279

Description

KO-947

Research Area

Signal Transduction

Key Properties

• CAS Number: 1695533-89-1
• MW: 355.39
• Purity: 96.81%
• Formula: C₂₁H₁₇N₅O
• SMILES: O=C1Nc2cc3[nH]nc(-c4ccncc4)c3cc2CN1Cc1ccccc1
• Target: ERK
• Solubility: DMSO:60 mg/mL (168.83 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.63 mM)

Bioactivity

• In Vitro:
  KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling, including mutations in KRAS, NRAS or BRAF, at low nanomolar concentrations.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KO 947, KO947, KO-947, inhibit, Inhibitor, ERK2, ERK, ERK1, Extracellular signal regulated kinases

Compound Identifiers

PubChem CID

136653617