KNK437

SKU: orb1305477

Description

KNK437

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 218924-25-5
• MW: 245.23
• Purity: 98.00%
• Formula: C₁₃H₁₁NO₄
• SMILES: O=CN1CCC(=Cc2ccc3OCOc3c2)C1=O
• Target: HSP
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:12 mg/mL (48.93 mM);10% DMSO+90% Corn Oil:1 mg/mL (4.08 mM)

Bioactivity

• In Vivo:
  KNK437 (200 mg/kg, i.p.) shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors. The same dose of KNK437 enhances the antitumor effects of fractionated heat treatment in a synergistic manner.
• Cell Research:
  Thermotolerance is induced by incubating cells with 300 μM sodium arsenite for 90 min. Cells are preincubated with or without 100 μM KNK437 for 1 h before the sodium arsenite treatment. After treatment of the cells with sodium arsenite, cells are washed once with PBS and incubated at 37℃ for 5 h with or without KNK437. The effects of KNK437 on acquired thermotolerance are tested by heating the cells at 45°C for the indicated time. The surviving fraction is calculated as the plating efficiency of the treated cells divided by the plating efficiency of untreated control cells.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HSP72, HSP40, HSP, HSP105, Inhibitor, Heat shock proteins, Heat Shock Protein Inhibitor I, inhibit, KNK 437, KNK437, KNK-437

Compound Identifiers

PubChem CID

24906297