KN-93 hydrochloride

SKU: orb1705023

Description

KN-93 hydrochloride

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 1956426-56-4
• MW: 537.5
• Purity: 99.99%
• Formula: C₂₆H₃₀Cl₂N₂O₄S
• SMILES: Cl.O=S(=O)(C1=CC=C(OC)C=C1)N(C=2C=CC=CC2CN(C)CC=CC3=CC=C(Cl)C=C3)CCO
• Target: CaMK,Autophagy

Bioactivity

• Target IC50:
  CaMK II:370 nM (Ki)
• In Vivo:
  KN-93 hydrochloride (1 mg/kg, intraperitoneal injection, for 12 consecutive weeks) significantly inhibited the constitutive activation of the CaMKII/NF-κB signaling pathway in the retina of STZ-induced diabetes mellitus rat models. It effectively reduced the expression levels of vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), and intercellular adhesion molecule-1 (ICAM-1), thereby markedly alleviating diabetes mellitus-induced retinal vascular leakage .
• In Vitro:
  In primary cultured rat retinal Müller cells, KN-93 hydrochloride (10 μmol/L, 24 hours) significantly inhibited the activation of the CaMKII/NF-κB signaling pathway induced by high Vitis vinifera sugar conditions, thereby reducing the mRNA and protein expression levels of inflammatory factors such as VEGF, iNOS, and ICAM-1 .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KN 93 Hydrochloride, KN93 hydrochloride, KN-93 Hydrochloride

Compound Identifiers

PubChem CID

73425340