KN-62

SKU: orb1305154

Description

KN-62

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 127191-97-3
• MW: 721.84
• Purity: 99.80%
• Formula: C₃₈H₃₅N₅O₆S₂
• SMILES: O=C([C@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)NCS(=O)(=O)c1cccc2cnccc12)N1CCN(CC1)c1ccccc1
• Target: P2X Receptor,Autophagy,CaMK
• Solubility: DMSO:125 mg/mL (173.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.77 mM)

Bioactivity

• Target IC50:
  CaMK II:0.9 μM(Ki)|CaMK V:0.8 μM(Ki)
• In Vivo:
  KN-62 inhibit the proliferation of K562 cells and blocks cell cycle progression. When administered at 10 μM to rat pancreatic islet cells, KN-62 inhibits Insulin secretion stimulated by carbachol and potassium. furthermore , KN-62 suppresse the phosphorylation of Ca2+ CaM kinase induced by A23187 in PC12 D cells.
• In Vitro:
  KN-62 administration in adult rats reduce the expression levels of brain-derived neurotrophic factor (BDNF) mRNA induced by epilepsy in the brain.
• Cell Research:
  For cell growth analysis, K562 cells are plated in a 3-cm dish with 5 mL of culture medium containing various concentration of KN-62. After two days in these condition cell numbers are counted. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HEK293 cells, inhibit, KN 62, KN62, KN-62, noncompetitive antagonism, autophosphorylation, Autophagy, Calmodulin-dependent protein kinases, Calmodulin-dependent kinases, CaMK, CaMKII, CaMKⅤ, P2X Receptor, P2XReceptor, P2XRs

Compound Identifiers

PubChem CID

23615788