KLH45

SKU: orb1703275

Description

KLH45 is a potent and selective small molecule inhibitor of the triglyceride hydrolase DDHD2 (SPG54), exhibiting an IC50 of 1.3 nM. This compound is a valuable chemical probe for investigating lipid metabolism and the pathogenesis of hereditary spastic paraplegia in both cellular and animal model studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1632236-44-2
• MW: 458.48
• Purity: >99.99% (May vary between batches)
• Formula: C₂₄H₂₅F₃N₄O₂
• SMILES: FC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)C1CCCCC1
• Target: Phosphatase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.91 mM);DMSO:162 mg/mL (353.34 mM)

Bioactivity

• In Vivo:
  KLH45 (20 mg/kg) significantly elevates brain triglycerides in DDHD2−/− mice.
• In Vitro:
  In Neuro2A cells, KLH45 (25 nM) completely inhibits DDHD2 (>95%). In fatty acid-supplemented DDHD2-expressing cells, KLH45 (2 μM) increases LD formation and selectively blocks DDHD2 activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DDHD2, KLH 45, KLH45, KLH-45

Compound Identifiers

PubChem CID

126970670