KL-11743

SKU: orb1298023

Description

KL-11743 is a small molecule inhibitor that disrupts glucose metabolism, leading to a rapid depletion of NADH and a marked increase in aspartate levels. This action forces a metabolic shift toward mitochondrial oxidative phosphorylation, making it a useful tool for studying cancer metabolism and bioenergetics in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1369452-53-8
• MW: 522.6
• Purity: 99.57% (May vary between batches)
• Formula: C₃₀H₃₀N₆O₃
• SMILES: CCOc1ccc2nc(nc(Nc3ccc(cc3)-c3cn[nH]c3)c2c1)-c1cccc(OCC(=O)NC(C)C)c1
• Target: transporter
• Solubility: DMSO:14 mg/mL (26.79 mM);10% DMSO+90% Corn Oil:2 mg/mL (3.83 mM)

Bioactivity

• Target IC50:
  GLUT4:68 nM (IC50)|GLUT3:90 nM (IC50)|GLUT1:115 nM (IC50)|GLUT2:137 nM (IC50)
• In Vitro:
  Patient-derived xenograft models of succinate dehydrogenase A (SDHA)-deficient cancers are specifically sensitive to KL-11743, providing direct evidence that TCA cycle-mutant tumors are vulnerable to GLUT inhibitors in vivo.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, KL11743, KL-11743, KL 11743, Inhibitor, GLUT, GLUT1, GLUT2, GLUT3, GLUT4, glucose, Glucose transporter, transporter

Compound Identifiers

PubChem CID

146345838