KKL-10

SKU: orb1303047

Description

KKL-10

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 952849-76-2
• MW: 364.22
• Purity: 99.98% (May vary between batches)
• Formula: C₁₄H₁₀BrN₃O₂S
• SMILES: Cc1ccc(cc1)-c1nnc(NC(=O)c2ccc(Br)s2)o1
• Target: Antibacterial,ribosome
• Solubility: DMSO:3.65 mg/mL (10.02 mM)

Bioactivity

• In Vitro:
  KKL-10 shows markedly antimicrobial activity against both fully and attenuated virulent strains of F. tularensis. The MIC against F. tularensis strain Schu S4 and LVS are 0.48 and 0.12 μg/mL, respectively. KKL-10 inhibits the intracellular growth of F. tularensis during all stages of infection. KKL-10 cannot affect macrophage function or viability. KKL-10 (17.5 μg/mL) produces cytotoxic effects of less than 5%. The combination of IFN-γ stimulation and KKL-10 can reduce the bacterial load by >99.9%. KKL-10 also inhibits the growth of F. tularensis inside eukaryotic cells and exhibits no toxicity to HepG2 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, inhibit, KKL10, KKL-10, KKL 10, Inhibitor, ribosome rescue

Compound Identifiers

PubChem CID

16854524