KKII5

SKU: orb1819114

Description

KKII5 is a potent LOX-1 lipoxygenase inhibitor with an IC50 of 19 µM, effectively suppressing lipid peroxidation. Its mechanism involves enhancing electron acceptance at active sites, making it a valuable tool for studying oxidative stress and inflammation in cellular and biochemical assays.

Research Area

Metabolism Research

Key Properties

• CAS Number: 6381-55-1
• MW: 266.36
• Purity: 97.44% (May vary between batches)
• Formula: C₁₆H₁₄N₂S
• SMILES: S=C1NC(C=C(N1)c1ccccc1)c1ccccc1
• Target: Lipoxygenase
• Solubility: DMSO:55 mg/mL (206.49 mM)

Bioactivity

• Target IC50:
  LOX1:19 μM
• In Vitro:
  KKII5 (100 μM) has a significant inhibitory effect on lipid peroxidation, with an inhibition rate of 98%. KKII5 interacts with HIS499 of the cavity by forming a π-π stacking interaction between the benzene ring of the molecule and the imidazole ring of HIS499.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LOX-1

Compound Identifiers

PubChem CID

2725891