KIN101

SKU: orb1309510

Description

KIN101 is a synthetic isoflavone that acts as an IRF-3 signaling agonist, promoting its nuclear translocation. This compound exhibits broad-spectrum antiviral activity in vitro against RNA viruses, including HCV and RSV, making it a useful research tool for studying innate immune pathways and host-directed antiviral strategies.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 610753-87-2
• MW: 395.22
• Purity: 99.46% (May vary between batches)
• Formula: C₁₆H₁₁BrO₅S
• SMILES: CS(=O)(=O)Oc1ccc2c(c1)occ(-c1ccc(Br)cc1)c2=O
• Target: Influenza Virus,Antifection,RSV,Anti-infection,HCV Protease
• Solubility: DMSO:32 mg/mL (80.97 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.06 mM)

Bioactivity

• Target IC50:
  Influenza virus:2 μM |DNV:>5 μM
• In Vitro:
  KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dengue, DNV, 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene, broad-spectrum, KIN101, KIN-101, KIN 101, inhibit, IRF-3, Influenza Virus, InfluenzaVirus, influenza virus, Isoflavone, Inhibitor, Hepatitis C virus, hepatitis, HCV, HCV Protease, HCVProtease, virus, Viral, RSV, RNA

Compound Identifiers

PubChem CID

1998840