KIN-8741

SKU: orb3135571

Description

KIN-8741 is a highly selective and orally active Type IIb c-Met inhibitor. It exhibits broad-spectrum activity against c-Met kinase mutations. KIN-8741 demonstrates antitumor activity in non-small cell lung cancer models with MET gene amplification and exon 14 deletion. It is applicable in research on c-Met-driven cancers, particularly advanced tumors harboring MET exon 14 skipping mutations and acquired resistance mutations.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 2941104-53-4
• MW: 511.47
• Formula: C₂₆H₂₃F₂N₃O₆
• SMILES: O(C=1C2=C(C=C(OC)C(O[C@H](CO)C)=C2)N=CC1)C3=C(F)C=C(NC(=O)C=4C(OC)=CC=NC4)C=C3F
• Target: c-Met/HGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

c-Met/HGFR