KIN-8194

SKU: orb2565902

Description

KIN-8194 is a potent, orally bioavailable dual inhibitor of HCK and BTK with sub-nanomolar IC50 values. It demonstrates activity against BTK inhibitor-resistant malignancies, including mantle cell lymphoma, by inhibiting proliferation and adhesion, and has shown in vivo efficacy in overcoming ibrutinib resistance in DLBCL xenograft models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 330786-01-1
• MW: 483.61
• Formula: C₂₈H₃₃N₇O
• SMILES: NC1=C2C(=NN(C2=NC=N1)[C@@H]3CC[C@H](CC3)N4CCN(C)CC4)C5=CC=C(OC6=CC=CC=C6)C=C5
• Target: Src,BTK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

6539953