KIM-161

SKU: orb3027974

Description

KIM-161 is a PIK3CA inhibitor. It demonstrates significant antiproliferative activity, with IC50 values of 1.428 and 1.562 µM against PI3KCA-mutant breast cancer cell lines MCF7 and T47D, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway, leading to ROS production. It is applicable for research on breast cancer and its PI3KCA-mutant subtypes.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2559686-28-9
• MW: 439.51
• Formula: C₂₇H₂₅N₃O₃
• SMILES: O=C\1N(C(C)=N/C1=C\C2=CC=C(OC)C=C2)C3=CC=C(CC(NCC4=CC=CC=C4)=O)C=C3
• Target: Reactive Oxygen Species,Akt,PI3K,mTOR,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Reactive Oxygen Species,Akt,PI3K,mTOR,Apoptosis