Kigamicin C

SKU: orb1692537

Description

Kigamicins are antitumor antibiotics with selective cytotoxicity against nutrient-starved pancreatic cancer cells, such as PANC-1, and exhibit antimicrobial activity against Gram-positive bacteria. Kigamicin D demonstrates in vivo efficacy by suppressing pancreatic tumor growth in mouse models, potentially through inhibition of Akt activation under nutrient stress. These compounds also induce necrosis in human myeloma cells while sparing normal lymphocytes.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 680571-51-1
• MW: 809.818
• Formula: C₄₁H₄₇NO₁₆
• SMILES: [H][C@]12Cc3cc4C[C@@]5(C)OCCN5C(=O)c4c(O)c3-c3c(O)c4c(oc5[C@@H](O)[C@@H](C[C@H](O)c5c4=O)O[C@H]4CC[C@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@@H](C)O5)[C@@H](C)O4)c(OCO1)c23
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11764292