KIF18A-IN-6

SKU: orb3027099

Description

KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM. It reduces HCC15 tumour volume in mouse models and may be employed in KIF18A-associated cancer research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2914879-10-8
• MW: 559.74
• Purity: 97.59%
• Formula: C₂₈H₃₇N₃O₅S₂
• SMILES: O=C(C1=CC=CC(=C1)S(=O)(=O)NC(C)(C)C)N2C3=CC=C(C=C3C4(C2)CCC5(CC4)CC5)NS(=O)(=O)CC
• Target: Microtubule Associated,Kinesin
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (5.9 mM);DMSO:100 mg/mL (178.65 mM)

Bioactivity

• Target IC50:
  KIF18A microtubule-dependent ATPase activity:0.016 μM
• In Vivo:
  KIF18A-IN-6 (10-60 mg/kg, once or twice daily for 1 month) administered orally effectively inhibited the growth of HCC15 and OVCAR3 tumors in mice.
• In Vitro:
  KIF18A-IN-6 demonstrates inhibitory effects on the viability of JIMT-1, HCC-15, and NIH-OVCAR3 cells, with corresponding IC50 values of 0.0040, 0.0051, and 0.0051 μM, respectively.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Microtubule Associated,Kinesin