KIF18A-IN-3

SKU: orb1685971

Description

KIF18A-IN-3 is a potent and selective KIF18A inhibitor with an IC50 of 61 nM. It functions by inducing mitotic arrest, a mechanism validated in cellular assays, and has been shown to increase mitotic cells within tumor tissues in vivo, supporting its use in cancer biology and oncology research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2600577-49-7
• MW: 574.76
• Purity: 98.45% (May vary between batches)
• Formula: C₂₈H₃₈N₄O₅S₂
• SMILES: O=C(NC1=CC=CC(=C1)S(=O)(=O)NC(C)(C)C)C2=CC=C(C=C2N3CCC4(CC3)CC4)NS(=O)(=O)C5(C)CC5
• Target: Microtubule Associated,Kinesin
• Solubility: DMSO:80 mg/mL (139.19 mM)

Bioactivity

• Target IC50:
  KIF18A:61 nM
• In Vivo:
  KIF18A-IN-3 (100 mg/kg, ip.) increased the number of mitotic cells (PH3-positive cells) in CD1 mouse tumor tissue for up to 24 hours.
• In Vitro:
  KIF18A-IN-3 is a potent KIF18A inhibitor with IC50 = 61 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155780813