Ki11502

SKU: orb3133188

Description

Ki11502 is a multi-target receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGFβ/α receptors (with an IC50 of less than 10 nM). It specifically suppresses PDGFβ receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Additionally, Ki11502 induces apoptosis and exhibits significant antiproliferative effects against specific leukemia subgroups, including those with Imatinib-resistant mutations. It is particularly suitable for studying the role of PDGF in vascular diseases and the involvement of proteoglycans in atherosclerosis.

Key Properties

• CAS Number: 347155-76-4
• MW: 473.54
• Formula: C₂₆H₂₃N₃O₄S
• SMILES: O=C(NC(=S)NC1=CC=C(OC=2C=CN=C3C=C(OC)C(OC)=CC32)C=C1)C=4C=CC=CC4C
• Target: Apoptosis,Akt,FLT,PDGFR,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Akt,FLT,PDGFR,Bcl-2 Family