KI-TOX-A3

SKU: orb3135305

Description

KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting the TOX protein, with an IC50 value of 0.51 μM for the TOX-KAT7 interaction. It promotes proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reverses CD8+ T cell exhaustion, and inhibits proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 holds potential for research in hematological malignancies, including T-ALL.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1351116-34-1
• MW: 319.31
• Formula: C₁₈H₁₃N₃O₃
• SMILES: N#CC1=C(N=C2C=3C=CC(O)=CC3CC2=C1C=4OC(=CC4)CO)N
• Target: Histone Acetyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Histone Acetyltransferase